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Maintenance fluids should not be used. Drug: Early Vasopressors Norepinephrine will be used as preferred vasopressor and titrated to achieve mean arterial pressure MAP between 65 mmHg and 75 mmHg. Liberal Fluids The general approach is to use fluid boluses to treat hypotension. Administer ml fluid boluses for fluid triggers until 5 liters administered or development of clinical s of acute volume overload develop.

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Maintenance fluids should not be used.

Drug: Early Vasopressors Norepinephrine will be used fuck finder chat preferred vasopressor and titrated to achieve mean arterial pressure MAP between 65 mmHg and 75 mmHg. Liberal Fluids The general approach is to use fluid boluses to treat hypotension. Administer ml fluid boluses for fluid triggers until 5 liters administered or development of clinical s of acute volume overload develop.

Any type of isotonic crystalloid normal saline, ringers lactate, balanced solution such as plasmalyte is permitted. Any day that a patient is alive and without organ support ttext represent days alive and free of organ support. Participants who do not survive to day 28 are ased zero ventilator-free days.

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Patients who died prior to day 28 are ased zero renal replacement free days. Patients who died prior to day 28 are ased zero vasopressor free days.

Patients who die on or prior to day 28 are ased zero hospital free days. Non-invasive mechanical ventilation will not be included as an outcome.

This is a binary outcome. Patients with chronic renal replacement therapy initiated prior to the current sepsis fuck finder chat will not be eligible to meet this endpoint. Patients on chronic renal replacement therapy will not be eligible for this endpoint determination. If a value is not available at baseline, it will be assumed to be normal.

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At the 72 hours assessment, if a value is missing then we will carry forward the closet ly known value. If a patient is intubated or heavily sedated at either 0 or 72 hours, the GCS will be omitted when calculating the change in score.

If a patient was on renal replacement therapy prior to presentation, then the renal dysfunction component to the SOFA score will be omitted as well. Talk with your doctor and family members or friends about deciding to a study.

To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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